Not a lot of batsmen lived up to the expectations which is a potential concern for Australia ahead of important matches coming up.
They came together at 55-3 in the 16th over with Miller swatting 139 for his fifth limited-overs century and skipper du Plessis smashing 125
The hosts, who were thrashed by six wickets in the opening match, dug deep with their bowlers getting them over the line
Siddle, who was named as cover for Starc in the recent T20I series against Pakistan, was also omitted from the 13-man squad.
Marsh had to miss the first ODI in Perth for minor surgery on an abscess in his buttock region.
"Elite honesty" was reportedly one phrase plastered on the walls of the team's changing room ahead of their one-day clash with South Africa in Perth
The home side slumped to a crushing six-wicket defeat with more than 20 overs to spare in the opening one-dayer in Perth on Sunday
The hosts came into the clash having lost 16 of their past 18 ODIs and with the reverberations of a ball-tampering scandal this year still hanging